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Tau Prevents Synaptic Transmission At Early Stage Of Neurodegeneration

Tau prevents synaptic transmission at early stage of neurodegeneration

These proteins clump together in patients' brains to form neuronal tangles: protein aggregation that eventually coincides with the death of brain cells. They immediately suggest a way to intervene in this process. Tau proteins are best known as the proteins that are stacked to form neuronal "tangles" in Alzheimer's patients' brains, but they also play a role in many other brain disorders such as Parkinson's and Huntington's disease. In the nerve cells of patients, however, tau is dislodged from the cytoskeleton and ultimately tangles together to form protein accumulations that disrupt the nerve cell's functioning. But even before these protein accumulations are formed, the dislodged tau impedes the communication between nerve cells. VIB's research team has described a new mechanism for this in the journal Nature Communications. Professor Patrik Verstreken (VIB-KU Leuven) explains: "We have demonstrated that when mutant tau dislodges from the cytoskeleton, it mainly settles at the synapses of the nerve cells. When tau settles at the synapse, it locks onto the vesicles, inhibiting synaptic transmission." They pave the way for a possible treatment. Patrik Verstreken already provided proof of principle: "If we stop tau from locking onto the vesicles in the nerve cells of rats and fruit flies, we can prevent the inhibition of synaptic transmission and also the death of nerve cells."
Diagnostic Biomarkers In Saliva Show Promise In Recognizing Early Alzheimer’s Disease

Diagnostic biomarkers in saliva show promise in recognizing early Alzheimer’s disease

Investigators at the Beaumont Research Institute, part of Beaumont Health in Michigan, are hopeful that their study involving small molecules in saliva will help identify those at risk of developing Alzheimer's disease - a neurologic condition predicted to reach epidemic proportions worldwide by 2050. Their study, "Diagnostic Biomarkers of Alzheimer's Disease as Identified in Saliva using 1H NMR-Based Metabolomics" was published in the Journal of Alzheimer's Disease. Investigators found salivary molecules hold promise as reliable diagnostic biomarkers. Investigators seek to develop valid and reliable biomarkers, diagnosing the disease in its earliest stages before brain damage occurs and dementia begins. Researcher Stewart Graham, Ph.D., said, "We used metabolomics, a newer technique to study molecules involved in metabolism. Metabolomics is used in medicine and biology for the study of living organisms. "Given the ease and convenience of collecting saliva, the development of accurate and sensitive biomarkers would be ideal for screening those at greatest risk of developing Alzheimer's. Dr. Graham said, "Worldwide, the development of valid and reliable biomarkers for Alzheimer's disease is considered the No. 1 priority for most national dementia strategies. The condition's toll not only affects millions of Americans, but in 2017, it could cost the nation $259 billion.


“It’s a wonderful world out there, swimming back and forth in the calming waters. So when I turned 50, I started walking everywhere I needed to go instead of taking public transportation, and I joined a gym. At 55, I joined a different gym—one that had a pool. Would I swim half a lap and then feel like I was going to die and give up? It turns out, science is on my side. By taking a lot of rests, I swam an incredible 14 laps that day. In New York City, where I live, I’ve found swimming groups to join and activities to engage in, including an annual lap swim contest with a dinner and party hosted by NYC Parks & Recreation. A tip for women: If you’re worried about the effect of chlorine on your locks, wet your hair, lather in some conditioner and cover it with your bathing cap while you swim. It’s a wonderful world out there, swimming back and forth in the calming waters. Instead of running on a treadmill, I brace my feet against the side of a pool and glide off into the bright blue buoyant world, swimming back and forth at whatever relaxing or invigorating pace I feel like taking that day.
How To Manage Stress At Any Age: Keep Calm And Carry On!

How to Manage Stress at Any Age: Keep Calm and Carry On!

How to Manage Stress at Any Age: Keep Calm and Carry On!. When I yelled at London, I felt angry, my blood pressure went up, I was frustrated and quite honestly didn’t enjoy the experience of being a dog mommy. Could I get more positive results in his training by staying centered, being firm, establishing rules? Would London and I both have a more positive experience in the same moment where just seconds ago I was out of control and yelling? Six Ways to Keep Calm When you find yourself reacting in a negative way to a person or situation, try the following: First, take a deep breath and count to 10. Quite honestly, most people don’t go around trying to make others angry. London was just being a puppy. I might be able (eventually) to teach him or share my perspective but he still comes from his own frame of reference. !” But when I stay calm, and try to understand his point of view – not always easy since he’s a dog – I find that I don’t yell quite so much and my world – and his – seems to run a lot more smoothly. How do you manage stress in your life?
Stayin’ Alive: How Music May Influence Your Medical Treatment

Stayin’ Alive: How Music May Influence Your Medical Treatment

Stayin’ Alive: How Music May Influence Your Medical Treatment. According to officials at New York’s Presbyterian Hospital, select rhythmic songs can help first responders and people trained in cardiopulmonary resuscitation administer hands-on CPR at the proper speed needed for it to be successful. For that to happen, each compression on the chest of a victim needs to be at about 100 beats a minute. A Playlist to Re-Spark a Heart Of course, “Stayin’ Alive” isn’t the only Baby Boomer-era song that could be a vital 100-beat aid in performing life-saving CPR. Health officials say such preparation can be invaluable. A study conducted by the Medical Journal of Australia, designed to explore the effects of rock and classical music on surgical speed, accuracy, and perceived distraction, showed a definite downside to loud rock. In fact, they didn’t even use real surgeons. Instead, more than 350 men and women who had no prior medical experience were selected to see what effects music had in the operating room. Each of the subjects performed “surgery” on the character “Cavity Sam” by using the popular board game “Operation” and removing three “organs.” While performing their “surgical” operations, the subjects were made to listen to the sounds of an actual operating room, classic music like Mozart and loud rock like AC/DC songs. The results showed that listening to rock music impaired men, but not women.
How To Relax And Relieve Stress With Your Very Own Home Retreat

How to Relax and Relieve Stress with Your Very Own Home Retreat

To save both cash and time you can set up a retreat for yourself – and maybe a friend or two – and enjoy a relaxed time of self-nurturing without leaving home. Let’s talk about how to relax and relieve stress with your very own home retreat. Realistically, a half-day or day of dedicated downtime is a good way to start with your first retreat. Talk the idea over with a few like-minded friends and make sure you’re all looking to achieve the same thing. Preparing Your Retreat Pre-planning makes all the difference to the success of your retreat, and this is true even if you’re starting with just a couple of hours on your own. Your experience will be more satisfying if it’s well-organised so that you can move easily through the time without having to stop and think about what’s next. Organise food and drink and supplies such as journaling materials, pens, paper, crayons, paints. A Simple Meditation Retreat Are you longing for peace and quiet, a chance to reflect and contemplate? We brought our own lunches and ate together in companionable silence, then enjoyed a walking meditation outdoors for 30 minutes, before ending our silence over tea and setting out for home, feeling calm and relaxed. Whether you love writing, painting, sculpting or any other activity, you can make your passion the focus of a retreat.
Do You Worry About Growing Older Alone? Here’s What To Do About It!

Do You Worry About Growing Older Alone? Here’s What to Do About it!

As a single small business owner who lives alone, I have spent a lot of time thinking about – and planning for – a potentially solo future. Four Things That Worry Me About Growing Old Alone As a single woman, my two greatest fears in life are outliving my money or my ability to earn money to support myself, and losing my health or mobility and becoming dependent on other people or institutions for care. I also worry about whether I will die alone, without a supportive circle of friends and family. How many years of money will you need? A part-time job or income from starting a business can relieve financial pressure and help fund activities and travel. Start walking, join a fitness or nutrition program, exercise with friends. Staying healthy and active is the best way to remain independent as you get older. We all need people nearby to offer advice or support, provide social interaction, get us out of the house and push us to try new things. Face Your Fears and Embrace Life Living a full and happy life as we grow older is about planning and choices. In my book, Retiring Solo, I discuss strategies that can help you plan for an independent future that is happy, healthy, active and filled with a sense of community.
University Of Birmingham Develops Revolutionary Eye Drops To Treat Age-related Blindness

University of Birmingham develops revolutionary eye drops to treat age-related blindness

Scientists at the University of Birmingham have developed a type of eye drop which could potentially revolutionise the treatment of one of the leading causes of blindness in the UK. The results of the collaborative research, published in Investigative Opthamology and Visual Science, could spell the end of painful injections directly into the eye to treat the increasingly common eye disorder known as age-related macular degeneration (AMD). AMD affects more than 600,000 people in the UK and predictions suggest this figure could rise sharply in future because of an ageing population. A painless condition which causes people to gradually lose their central vision, usually in both eyes, AMD is currently treated by repeated injections into the eye on a monthly basis over at least three years. This is a problem because, apart from being an unpleasant procedure for patients to undergo, the injections can cause tearing and infections inside the eye and an increased risk of blindness. Now scientists led by biochemist Dr Felicity de Cogan, from the University of Birmingham's Institute of Inflammation and Ageing, have invented a method of delivering the injected drug as an eye drop instead, and their laboratory research has obtained the same outcomes as the injected drug. Dr de Cogan said: "The CPP-drug has the potential to have a significant impact on the treatment of AMD by revolutionising drug-delivery options. "Efficacious self-administered drug application by eye drop would lead to a significant reduction in adverse outcomes and health care costs compared with current treatments. "The CPP-plus drug complex also has potential application to other chronic ocular diseases that require drug delivery to the posterior chamber of the eye. Article: Topical Delivery of Anti-VEGF Drugs to the Ocular Posterior Segment Using Cell-Penetrating Peptides, Felicity de Cogan; Lisa J. Hill; Aisling Lynch; Peter J. Morgan-Warren; Judith Lechner; Matthew R. Berwick; Anna F. A. Peacock; Mei Chen; Robert A. H. Scott; Heping Xu; Ann Logan, Investigative Opthamology and Visual Science, doi:10.1167/iovs.16-20072, published May 2017.
Over 50? Maybe It’s Time To Upgrade Your Tooth Brushing Technique!

Over 50? Maybe it’s Time to Upgrade Your Tooth Brushing Technique!

Maybe it’s Time to Upgrade Your Tooth Brushing Technique!. Find out if you are using the best brush for your needs, perfect your brushing technique and tweak your timing to give your teeth and gums the best possible chance to prevent tooth decay and gum disease. When it Comes to Your Tooth Brushing Technique, Softer is Better Always choose the softest bristles for your toothbrush to avoid scratching or gouging the surface of your teeth with a firm toothbrush. Speedy electric toothbrushes increase the impact of your tooth brushing technique, so it’s even more important to use a soft bristled head and hold lightly against your teeth than with a manual toothbrush. Brushing carelessly into your gums contributes to receding gums, gum pockets or abrasions that can lead to gum disease. If you have receding or bleeding gums you really need to use soft, round-tipped bristles and brush very, very gently. The best time to brush in the morning is as soon as you get up, to give your mouth a fresh start for the day. You should spend at least two or three minutes brushing each tooth surface individually, stroking away from the gum. Your teeth cleaning time is the best time to think loving thoughts towards your teeth and gums, and forgive yourself any imperfections. Do you feel like you take good care of your teeth?
6 Ways To Overcome The Betrayal Of The Body After 60

6 Ways to Overcome the Betrayal of the Body After 60

My body has betrayed me. As our physical body gets older, we have to find new ways to move and celebrate it. And you don’t need a mountain trail; you can walk in the town where you live. Age Appropriate Exercise You can’t tell, but I rolled my eyes when I wrote that heading. However, if you are looking for lifelong practices, the age appropriate part does apply. Dancing is something you can do in your living room too. Walking is my main exercise. As I move deeper into age, I find that an attitude of gratitude serves whatever I do. I’m thankful that my little town offers classes in yoga, Pilates, dance and swimming. How are you moving now that there are some physical limitations to your activity?