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The Protein CHIP Unfurls Anti Aging Activity

The protein CHIP unfurls anti-aging activity

Researchers at the universities of Cologne and Bonn uncover the link between protein aggregation and aging.

Not only does our way of life determine how long we live but so too does our genetic material. Of particular importance here is a genetic program that is controlled by the insulin receptor. A team of researchers from the Universities of Cologne and Bonn has now discovered how protein aggregation affects this genetic program and thus triggers aging. The results have now been published in the journal Cell.

Early in evolution, sugar intake and the regulation of life span were linked with each other. The hormone insulin is crucial here. It reduces blood sugar levels by binding to its receptor on the cell surface. However, many processes for stress management and survival are shut down at the same time. When there is a good supply of food, they appear unnecessary to the organism, although this reduces life expectancy over the long term. The insulin receptor thus acts like a brake on life expectancy. Genetically altered laboratory animals in which the insulin receptor no longer functions actually live much longer than normal. But how is the insulin receptor normally kept in check in our cells and…

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