Protein in human umbilical cord blood rejuvenates old mice's impaired learning, memory.
The lead author is former postdoctoral scholar Joseph Castellano, PhD, who is now an instructor of neurology and neurological sciences.
To distinguish the effects of old, young and "youngest" human blood on hippocampal function, the researchers used immune-deficient laboratory mice that could be given repeated injections of human plasma without experiencing negative immune reactions.
The table is also full of holes, one of which is attached to a tube in which a scared mouse can find darkness and safety.
And older mice's performance on the Barnes maze and other tests was stellar in comparison with mice of the same age who got injections of saline instead of plasma.
But older mice that were given human cord plasma depleted of TIMP2 derived no learning and memory benefits. "TIMP2's effects in the brain have been studied a little, but not much and not in aging," said Castellano. "In our study, it mimicked the memory and learning effects we were getting with cord plasma.
And it appeared to do that by improving hippocampal function."
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice.